To get to Canifis in OSRS, you need to complete the Priest in Peril quest first. This quest serves as the basic requirement to enter Morytania, where Canifis is located.
The quest is relatively simple, requiring you to defeat two level 30 enemies. After completing Priest in Peril, multiple transportation methods become available.
The fastest method is using the Kharyrll Teleport from the ancient spellbook. Players who want to invest in their Player-Owned House can build a Kharyrll teleport portal for convenient access.
If you need help gathering resources for construction, you can buy OSRS gold from trusted marketplaces like Chicks Gold to speed up the process.
For players without access to these teleports, the Salve Graveyard teleport scroll offers a quick alternative with no requirements. The Fenkenstrain's Castle teleport scroll also works effectively. Both scrolls can be purchased from the Grand Exchange.
Players with Slayer rings can teleport to the Slayer Tower, which sits close to Canifis. The CKS fairy ring also provides a nearby teleport option for those who have unlocked the fairy ring network.
A community-based solution exists in World 330, specifically in Rimmington. Players often host their houses with Kharyrll teleport portals, making this a reliable option for reaching Canifis.
The basic route remains walking through Paterdomus temple after completing Priest in Peril. Enter the temple basement, pass through the holy barrier, and proceed north to reach Canifis. This werewolf-inhabited town sits east of Paterdomus, across the River Salve, in the dark region of Morytania.